#Iota carrageenan covid trial

Hydroxychloroquine did not prevent COVID-19 used as pre or postexposure prophylaxis. Except for studies on vaccines we only found three peer-reviewed publications available on the efficacy of Hydroxycholoquine to prevent COVID-19 disease in individuals at risk of exposure.

We searched PubMed for research articles published up to February 14, 2021, with no language restrictions, using the terms “SARS-CoV-2” or “COVID-19”, “prevention”, “clinical trial”, and “prophylaxis”. Research in context Evidence before this study I-C showed significant efficacy in preventing SARS-Cov-2 infection in hospital personnel dedicated to care patients with COVID-19 disease. There were no differences in the incidence of adverse events across the two groups (17♳% in the I-C group and 15♲% in the placebo group, p= 0♵). Workday loss in placebo group compared to I-Cc were 1.6% days / person (95% ci, 1.0 to 2.2) p <0.0001 The incidence of COVID19 was significantly lower in the I-C group compared to placebo (1♰% vs 5♰%) (Odds Ratio 0♱9 (95% confidence interval 0♰5 to 0♷7 p= 0♰3). Both treatment groups had similar baseline characteristics.

#Iota carrageenan covid trial

The trial is registered at (Ī total of 394 individuals were randomly assigned to receive I-C or placebo. The primary end point was clinical COVID-19, as confirmed by reverse-transcriptase–polymerase-chain-reaction testing, over a period of 21 days.

This is a pragmatic multicenter, randomized, double-blind, placebo-controlled trial assessing the use of a nasal spray containing I-C in the prophylaxis of COVID-19 in hospital personnel dedicated to care of COVID-19 patients.Ĭlinically healthy physicians, nurses, kinesiologists and others medical providers were assigned in a 1:1 ratio to receive four daily doses of I-C spray or placebo for 21 days. In vitro, I-C inhibits SARS-CoV-2 infection in cell culture. Iota-Carrageenan (I-C) is a sulfate polysaccharide synthesized by red algae, with demonstrated antiviral activity and clinical efficacy as nasal spray in the treatment of common cold.